Skin3D: Detection and longitudinal tracking of pigmented skin lesions in 3D total-body textured meshes

•Deep-learning and optimization based approach to track lesions on 3D total-body scans.•3D textured meshes are unwrapped to leverage 2D region detection approaches.•Detected lesions are mapped to 3D coordinates and tracked across 3D meshes.•Automated approach to detect skin lesions performs similar to human annotators.•Publicly release over 25,000 manual annotations of lesions on 3D body scans.