Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease

Mohammad Farhadi,Mahdi Eskandarian Boroujeni,Seyed Kamran Kamrava,Zohreh Bagher,Ava Modirzadeh Tehrani,Fakhroddin Aghajanpour,Samira Ezi,Reza Soltani,Aysan Khatmi,Rafieh Alizadeh

Journal of Chemical Neuroanatomy（2021）

引用 9|浏览5

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摘要

•Transplantation of OE-MSCs provokes overexpression of DAergic markers in the striatum of PD models.•Grafting of OE-MSCs improves motor coordination and muscle activity in 6-OHDA model of PD.•OE-MSCs implantation ameliorates locomotor performance in PD rat models.

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关键词

Parkinson’s disease,Cell replacement therapy,Human olfactory ecto-mesenchymal stem cells,Motor skills,Dopaminergic markers

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