Characterization Of T Lymphocytes In Severe Covid-19 Patients

Daniela Fenoglio,Chiara Dentone,Alessia Parodi,Antonio Di Biagio,Federica Bozzano,Antonio Vena,Marina Fabbi,Francesca Ferrera,Tiziana Altosole,Bianca Bruzzone,Mauro Giacomini,Paolo Pelosi,Andrea De Maria,Matteo Bassetti,Raffaele De Palma,Gilberto Filaci

JOURNAL OF MEDICAL VIROLOGY（2021）

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摘要

In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.

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关键词

adaptive immunity, COVID-19, SARS-CoV-2, T lymphocytes

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