One Step Carboxyl Group Isotopic Labeling For Quantitative Analysis Of Intact N-Glycopeptides By Mass Spectrometry Dagger
CHEMICAL COMMUNICATIONS(2021)
摘要
Here, we have developed an approach termed methylamine stable isotope labeling (MeSIL) to relatively quantify N-glycopeptides through one step labeling. It is the first time that this approach is applied to measure N-glycopeptide changes in huh7 cells after Zika virus infection and it has been revealed that differentially expressed N-glycopeptides played important roles in virus infection at the glycosylation site-specific level.
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关键词
mass spectrometry,step carboxyl group,isotopic labeling,n-glycopeptides
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