Efficacy of intra-articular corticosteroid injections in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

•Intraarticular glucocorticoid injections are efficient to reduce pain and improve function in the early phase (<=6 weeks) of symptomatic knee OA.•Intraarticular glucocorticoid injections are not superior to other interventions such as Intraarticular hyaluronic acid injections or physiotherapy in a long-term (>=24 weeks) perspective.•Intraarticular glucocorticoid injections should be considered for the medical treatment of knee OA in a timely manner.•Safety aspects should be considered and further studies are warranted to assess the effect of intraarticular glucocorticoid injections on cartilage.