Efficient Preparation Of Ellman'S Imines From Trifluoromethyl Ketones Promoted By Zirconium(Iv) Tert-Butoxide

Toshio Kawanami,Alexander S. Karns,Christopher M. Adams,Michael Serrano-Wu

Tetrahedron Letters（2013）

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摘要

An efficient synthesis of chiral N-tert-butanesulfinyl trifluoromethyl ketimines by using zirconium(IV) tert-butoxide is described. Compared to conventional titanium(IV) ethoxide, this protocol gave better result especially for sterically hindered ketones. In addition to the high reactivity, a high degree of enantiopurity of the N-tert-butanesulfinyl group is retained. (C) 2013 Elsevier Ltd. All rights reserved.

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关键词

Zirconium(IV) tert-butoxide,N-tert-Butanesulfinyl trifluoromethyl,ketimines,Chiral alpha-CF3-amines,Imine formation

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