Introduction Of Orf3a-Q57h Sars-Cov-2 Variant Causing Fourth Epidemic Wave Of Covid-19, Hong Kong, China

Daniel K W Chu,Kenrie P Y Hui,Haogao Gu,Ronald L W Ko,Pavithra Krishnan,Daisy Y M Ng,Gigi Y Z Liu,Carrie K C Wan,Man-Chun Cheung,Ka-Chun Ng,John M Nicholls,Dominic N C Tsang,Malik Peiris,Michael C W Chan,Leo L M Poon

EMERGING INFECTIOUS DISEASES（2021）

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摘要

We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.

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COVID-19,China,Hong Kong,SARS,SARS-CoV-2,coronavirus,coronavirus disease,respiratory infections,severe acute respiratory syndrome coronavirus 2,viruses,zoonoses

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