Interference of C6O4 on platelet aggregation pathways: Cues on the new-generation of perfluoro-alkyl substance

•Exposure to legacy PFAS associates with endocrine disruption and health concerns.•Legacy PFOA was demonstrated to increase basal platelet pro-aggregation profile.•Supposed with a lower accumulation profile, novel C6O4 is expected to be with safer.•C6O4 equally accumulates on platelets membrane likely altering their properties.•C6O4 increases in vitro platelets aggregation profile and micro-particles production.