Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery

Cláudia Azevedo,Soraia Pinto, Sopisa Benjakul,Jeannette Nilsen,Hélder A. Santos,Giovanni Traverso,Jan Terje Andersen,Bruno Sarmento

Advanced Drug Delivery Reviews（2021）

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摘要

•The symptomatology of diabetes must be controlled to prevent fibrosis development.•FcRn mediates cellular recycling and transcytosis of IgG and albumin.•Linking antidiabetic peptides to FcRn-targeted molecules extends their half-life.•Nanoparticles protect antidiabetic peptides from harsh conditions in the GIT.•FcRn-targeted nanosystems can improve oral bioavailability of antidiabetic drugs.

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关键词

Antidiabetic peptides,FcRn,IgG,Albumin,Intestinal epithelium,Transcytosis,Half-life,Nanoparticles,Active targeting,Transgenic mouse model

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