Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

Rens Zonneveld,Suzanne Jurriaans,Tom van Gool,Jorrit J Hofstra, Thecla A M Hekker, Pien Defoer,Patricia E Broekhuizen-van Haaften,Ellen M Wentink-Bonnema,Lynn Boonkamp,Charlotte E Teunissen,Annemieke C Heijboer,Frans Martens,Godelieve de Bree,Michele van Vugt,Robin van Houdt

Journal of Clinical Virology（2021）

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摘要

•Head-to-head validation of SARS-CoV-2 immunoassays remains needed.•Sensitivity of the Wantai ELISA was unparalleled by five other immunoassays.•A simple rapid immunoassay (Biozek) with off-laboratory applicability compared favorably to immunoassays for automated analyzers.•Immunoassays may help to diagnose COVID-19 in hospitalized patients after 10 days post symptom onset.

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RIA,CLIA,CMIA,ECLIA,SIMOA

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