Chemo-Enzymatic Synthesis Of Lacto-N-Biose I Catalyzed By Beta-1,3-Galactosidase From Bacillus Circulans Using 4,6-Dimethoxy-1,3,5-Triazin-2-Yl Beta-Galactopyranoside As A Glycosyl Donor
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(2021)
摘要
Chemo-enzymatic synthesis of lacto-N-biose I (LNB) catalyzed by beta-1,3-galactosidase from Bacillus circulans (BgaC) has been developed using 4,6-dimethoxy-1,3,5-triazin-2-yl beta-galactopyranoside (DMT-beta-Gal) and GlcNAc as the donor and acceptor substrates, respectively. BgaC transferred the Gal moiety to the acceptor, giving rise to LNB. The maximum yield of LNB was obtained at the acceptor : donor substrate ratio of 1:30.
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关键词
beta-1,3-galactosidase, triazinyl glycoside, transglycosylation, lacto-N-biose I
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