Extracellular histones aggravate inflammation in ARDS by promoting alveolar macrophage pyroptosis

Ping Jiang,Yang Jin,Meng Sun,Xuemei Jiang,Jie Yang,Xin Lv,Zongmei Wen

Molecular Immunology（2021）

引用 11|浏览7

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摘要

•Extracellular histones may be causal in lung inflammation.•Alveolar macrophage pyroptosis is associated with acute lung injury.•Extracellular histones correlate well with alveolar macrophage pyroptosis.•Targeting histones or cell pyroptosis may be a reasonable therapeutic strategy.

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关键词

ARDS,Extracellular histones,Alveolar macrophage (AM),Pyroptosis

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