α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson’s disease in Mexican Mestizos

Alma Cristina Salas-Leal,Sergio M. Salas-Pacheco, Jesús A. Pérez Gavilán-Ceniceros,Francisco X. Castellanos-Juárez,Edna M. Méndez-Hernández,Osmel La Llave-León,Abelardo Camacho-Luis,Gerardo Quiñones-Canales,Elizabeth Romero-Gutiérrez,Oscar Arias-Carrión,José M. Salas-Pacheco,Ada A. Sandoval-Carrillo

Neuroscience Letters（2021）

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摘要

•Combination of plasmatic α-synuclein and SNP rs356219 could be useful as a multi-modal biomarker for Parkinson’s disease.•The blood biomarker can discriminate Parkinson’s disease patients from healthy subjects.•The blood biomarker identifies Parkinson’s disease at early stages.

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关键词

α-Synuclein,rs356219,SNCA mRNA levels,Parkinson's disease,Blood biomarker

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