A systematic review on genome-wide association studies exploring comorbidity in bipolar disorder

Journal of Affective Disorders Reports(2021)

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摘要
•We identified six GWAS with bipolar disorder I (BDI) and comorbid conditions (migraine, externalizing disorders and eating disorders)•Some genes involved in neurotransmission, stress response, neurogenesis and synaptic plasticity may be specifically associated with comorbid BDI.•Evidence from these GWAS is too weak to consider new endophenotypes in BDI.
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关键词
Bipolar disorder,Comorbidity,Endophenotype,Single nucleotide polymorphism,Genome-wide association study
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