The Prevent Ovarian Cancer Program (POCP): Identification of women at risk for ovarian cancer using complementary recruitment approaches

Gynecologic Oncology(2021)

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摘要
•Due to limits in Ontario’s genetic testing criteria, we tested first-degree relatives of deceased ovarian cancer patients.•Pathogenic variants were found in 10% of participants; rates were highest when a relative was diagnosed prior to age 60.•All participants discussed results with their relatives and engaged in enhanced screening or risk reduction.•Our findings support changing genetic testing guidelines in Ontario and provide a framework to notify eligible individuals.
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关键词
High-grade serous ovarian cancer,Unaffected first-degree relatives,Panel-based genetic testing,Pathogenic variants,Combined recruitment approaches
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