Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset

Shirin Kalimuddin,Christine Yl Tham,Martin Qui,Ruklanthi de Alwis,Jean Xy Sim,Joey Me Lim,Hwee-Cheng Tan,Ayesa Syenina,Summer L Zhang,Nina Le Bert,Anthony T Tan,Yan Shan Leong,Jia Xin Yee,Eugenia Z Ong,Eng Eong Ooi,Antonio Bertoletti,Jenny G Low

Med（2021）

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摘要

Protective immunity must develop coincidentally with vaccine efficacy onset80% of vaccinees develop spike-binding antibodies at day 10 after the first dose100% of vaccinees develop spike-specific T cells at the same time pointLack of neutralizing antibodies suggest they are not necessary to prevent COVID-19

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关键词

COVID-19,RNA vaccine,vaccine efficacy,T cells,binding antibodies,neutralizing antibodies

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