Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease.

Fabienne Cyprien,Claudine Berr,Jerome J Maller,Chantal Meslin,Mélissa Gentreau,Thibault Mura,Audrey Gabelle,Philippe Courtet,Karen Ritchie,Marie-Laure Ancelin,Sylvaine Artero

Psychological medicine（2021）

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摘要

High CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies.

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关键词

Alzheimer Disease,Cerebral white matter,Personality,cohort,corpus callosum,risk factor

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