Comprehensive exploration of tumor mutational burden and immune infiltration in diffuse glioma

•Higher tumor mutational burden indicated worse prognosis in diffuse glioma.•A gene risk score model was constructed based on the expression of hub genes.•Combined with clinical features, a prognostic nomogram was built and validated.•Immune infiltration was correlated to tumor mutational burden and prognosis.•An immune risk score model was constructed based on the proportion of immune cells.