CDX2 regulates ACE expression in blood development and leukemia cells

Reine El Omar,Emmanuelle Julien,Katia Biasch,Blandine Guffroy,Bruno Lioure,Laurent Vallat,Isabelle Gross,Claire Domon-Dell,François Lanza,Christian Gachet,Matteo Negroni,Jean-Noël Freund,Manuela Tavian

Blood Advances（2021）

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摘要

Expression of caudal-related homeobox gene 2 (CDX2) and angiotensin-converting enzyme (ACE) correlates during hematopoietic emergence. This emergence occurs in human and mouse embryos and in human acute myeloid leukemia; CDX2 homeoprotein also binds to the ACE promoter.

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关键词

ace expression,leukemia,cells,blood development

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