Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke

Elizabeth S. Waters,Erin E. Kaiser,Xueyuan Yang,Madison M. Fagan,Kelly M. Scheulin,Julie H. Jeon,Soo K. Shin,Holly A. Kinder,Anil Kumar,Simon R. Platt,Kylee J. Duberstein,Hea Jin Park,Jin Xie,Franklin D. West

IBRO Neuroscience Reports（2021）

引用 8|浏览4

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摘要

•Tanshinone IIA loaded nanoparticles demonstrate antioxidative capabilities in neural stem cell cultures.•Tanshinone IIA loaded nanoparticles leads to reduced lesion volume, midline shift, and white matter damage post-stroke.•Tanshinone IIA loaded nanoparticle treatment leads to marked improvements in spatiotemporal and kinetic gait parameters.

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关键词

FDA,ICH,Tan IIA,PLGA,Tan IIA-NPs,tPA,NP,ROS,DAMPS,TNF-α,IL-6,PEG–PLGA,BBB,CSF,CNS,STAIR,WM,GM,GABA,Tan IIA-NPs,MLS,PLGA-b-PEG-OH,Piog,Baic,Puer,Edar,Resv,TEM,PBS,SOD,IC,UGA,IM,TD,MCA,MCAO,T2FLAIR,T2W,T2*,DWI,DTI,ADC,FA,ddH2O,ANOVA,AU,NSCs,LPS,DLS

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