Musculin Is Highly Enriched In Th17 And Il-22-Producing Ilc3s And Restrains Pro-Inflammatory Cytokines In Murine Colitis

Jun Yan,Jing Yu,Shunzong Yuan,Wanqi Tang,Wei Ma,Xue Yang,Yijia Liu,Huaping Liang,Xuemei Zhong,Jing Shao,Yang Cao,Changchuin Mao,Richard Near,Wenda Gao

European Journal of Immunology（2021）

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摘要

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis. *

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关键词

Transcription factor, Musculin, Th17, ILC3, IL-22

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