Bacteria isolated from the stools of Alzheimer's disease patients exacerbate cognitive impairment in a 3xTg AD mouse model.

The microbiota of AD patients induced an AD-like phenotype in 3xTg mice, and microbiota from patient resilient to AD pathology induced a better memory score. Brain and gut ex-vivo assessments, 16S rRNA gene sequencing as well as behavioral longitudinal analysis are on-going to evaluate the human microbiota transplantation efficiency and its effect on AD pathology and inflammation.