Dmap-Catalyzed C-N Bond Formation For Diverse Synthesis Of Imidazo[1,2-A]Pyrimidine And Pyrimido[1,2-A]Benzimidazole Derivatives

A Summary of main observation and conclusion A DMAP (2-dimethylaminopyridine)-catalyzed condensation reactions for the successful direct construction of pyrimido[1,2-a]benzimidazole or imidazo[1,2-a]pyrimidine has been developed. The method utilizes readily available alpha-bromocinnamaldehydes with 2-aminobenzimidazole or 2-aminoimidazole as starting materials in the presence of 2-DMAP/TBHP. In the process, two C-N bonds were successfully constructed to synthesize target compounds. The current method features wide substrate scope, product diversification, and metal-free conditions.