Design, Synthesis And Antibacterial Activity Of N-Aryl-3-(Arylamino)-5-(((5-Substituted Furan-2-Yl) Methylene)Amino)-1h-Pyrazole- 4-Carboxamide As Nitrofurantoin (R) Analogues

Nitrofurantoin (R) is an effective drug and used for treating urinary infectious diseases. A series of nitrofurantoin (R) analogues bearing furan and pyrazole scaffolds as N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide ( 7a-g and 9a-f) were designed and synthesized by the condensation of 5-aminopyrazole with 5-nitrofuran-2-carbaldehyde (6) or 5-methylfuran-2-carbaldehyde (8) for evaluation of their antibacterial properties against Gram +ve and Gram - ve bacteria then comparing with nitrofurantoin (R) as standard drug.