The in vitro effects of hepatoblastoma cells on the growth and differentiation of blasts in transient abnormal myelopoiesis associated with Down syndrome

•Fetal liver origin of transient abnormal myelopoiesis (TAM) in Down syndrome.•Hepatoblasts regulate the growth and differentiation of TAM blasts in vitro.•Hepatoblasts produce stem cell factor and thrombopoietin.•Fetal liver microenvironment plays a role in leukemogenesis.