Oral DNA vaccination targeting VEGFR2 combined with anti-PDL1 avelumab in patients with progressive glioblastoma: Safety run-in results—NCT03750071.

Wolfgang Wick,Antje Wick,Olivier L. Chinot,Martin J. Van Den Bent,Filip Yves Francine Leon De Vos,Marc Mansour,Lilli Podola,Heinz Lubenau,Michael Platten

Journal of Clinical Oncology（2020）

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摘要

3001Background: VEGFR2 overexpression in glioblastoma serves as a target for VEGFR2 primed T cells using VXM01 DNA vaccine encoding for VEGFR2. VXM01 is delivered in a bacterial Ty21a carrier suita...

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关键词

DNA vaccination,Ty21a,Avelumab,Cancer research,Medicine,Glioblastoma,In patient,VEGF receptors

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