Discovery and Optimization of 2H-1Λ2-pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Jason M Rohde,Surendra Karavadhi,Rajan Pragani,Li Liu,Yuhong Fang,Weihe Zhang,Andrew McIver,Hongchao Zheng, Qingyang Liu,Mindy I Davis,Daniel J Urban,Tobie D Lee,Dorian M Cheff,Melinda Hollingshead,Mark J Henderson,Natalia J Martinez,Kyle R Brimacombe,Adam Yasgar,Wei Zhao,Carleen Klumpp-Thomas,Sam Michael,Joseph Covey,William J Moore,Gordon M Stott,Zhuyin Li,Anton Simeonov,Ajit Jadhav,Stephen Frye,Matthew D Hall,Min Shen,Xiaodong Wang,Samarjit Patnaik,Matthew B Boxer Journal of Medicinal Chemistry（2021）
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