UHPLC-MS/HRMS method for the quantitation of pyrithione metabolites in human urine

Ann Zoller,Kenneth Wehmeyer,Kady Krivos,Michael Karb,Peter Stoffolano,J F Nash,Guhan Balan, Lynda Behymer,Molly Seeck,Jose Brum,Yuanshu Zou,Jason Price

Journal of Chromatography B（2021）

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摘要

•Major urinary metabolites of zinc pyrithione confirmed for the first time in vivo.•UHPLC-MS/HRMS assay enabled better selectivity, LOQs than conventional LC-MS/MS.•Simple “dilute and shoot” assay with short run time for clinical sample analysis.•Commercial urine lots contained trace levels of pyrithione metabolites.

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关键词

Pyrithione,Urinary metabolites,Pyrithione glucuronide,Thiopyridine glucuronide,High resolution mass spectrometry

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