Harpagide exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress via SERCA following oxygen-glucose deprivation/reoxygenation injury

Ke Wang,Tao Wang,Huang Xu,Xiaoming Zhong,Zhen Huang

Neuroscience Letters（2021）

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摘要

•Maintaining SERCA activity to suppress ERS-mediated apoptosis is a new approach for protecting against CIRI.•Harpagide inhibits ERS by regulating calcium homeostasis.•Harpagide targets SERCA to protect against CIRI by suppressing ERS-mediated apoptosis.

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关键词

Harpagide,Cerebral ischemia reperfusion injury,SERCA,Cytoplasmic calcium concentration,Lentivirus

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