HYPOXIC-TUMOR-TARGETING SHORT-CHAIN POLYPEPTIDE MICROMOLECULE SELF-ASSEMBLY NANOMETER MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF

Provided are a preparation method for a hypoxic-region-targeting short-chain polypeptide micromolecule self-assembly nanometer material, and the use thereof. The nanometer material is a micromolecule carbonic anhydrase inhibitor modified by a short-chain polypeptide, wherein the N terminus of the short-chain polypeptide is bound to a substituted or unsubstituted aromatic group. By means of targeting carbonic anhydrase, which is highly expressed on a hypoxic tumor cell membrane, tumor micro-environment in-situ responsive self-assembly is realized, and specific endocytosis of the hypoxic tumor cells is induced, so that hypoxic tumor cells are regulated, controlled, killed and damaged. The material is simple in terms of preparation process, has higher biological safety, can effectively kill and damage the hypoxic tumor cells, can significantly improve conventional clinical chemotherapy treatment effects, can retard the tumor metastasis process and can provide more thinking and means for clinical tumor treatment.