Physiological and Biochemical Changes in NRF2 Pathway in Aged Animals Subjected to Brain Injury.

Marika Cordaro,Ramona D'Amico,Rossana Morabito,Roberta Fusco,Rosalba Siracusa,Alessio Filippo Peritore,Daniela Impellizzeri,Tiziana Genovese,Rosalia Crupi,Enrico Gugliandolo,Angela Marino,Rosanna Di Paola,Salvatore Cuzzocrea

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

Preserving and keeping the NRF-2 pathway active counteracts the onset of oxidative stress and consequent inflammation after ischemic and traumatic brain insult, particularly in the elderly. Not only that, NRF-2 pathway could represent a possible therapeutic target in the management of brain injuries.

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关键词

Nrf2, Oxidative stress, Aging, Inflammation, Brain injuries

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