Outcomes of Thermal Ablation of the Mucosal Defect Margin After Endoscopic Mucosal Resection: A Prospective, International, Multicenter Trial of 1000 Large Nonpedunculated Colorectal Polyps

In this prospective study, 1037 large nonpedunculated colorectal polyps that underwent successful endoscopic mucosal resection with complete thermal ablation of the defect margin after endoscopic mucosal resection were enrolled. Recurrence at first surveillance colonoscopy occurred in 10/707 cases (1.4%). In an international multicenter cohort of more than 1000 large nonpedunculated colorectal polyps, thermal ablation of the defect margin after endoscopic mucosal resection significantly reduced the frequency of recurrence at first surveillance colonoscopy.