Inflammatory Markers During Early Treatment Of Seroconverters In A Randomized Placebo-Controlled Trial Of Prep (Anrs-Ipergay)

Sylvain Chawki,Isabelle Charreau,Audrey Gabassi,Diane Carette,Eric Cua,Laurent Cotte,Gilles Pialoux,Claire Pintado,Laurence Meyer,Marie-Laure Chaix,Constance Delaugerre,Jean-Michel Molina

OPEN FORUM INFECTIOUS DISEASES（2021）

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摘要

HIV-related inflammation is associated with poor outcomes. We describe inflammatory biomarkers in 17 participants in a pre-exposure prophylaxis trial who seroconverted with very early initiation of antiretroviral therapy. Inflammation peaked at the time of HIV infection and returned to baseline within 6-12 months. Starting antiretroviral therapy very early could help mitigate long-lasting HIV-related inflammation.

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CRP, D-dimers, early antiretroviral therapy, HIV, IL6, PrEP, sCD14

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