Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer’s disease in the 3xTgAD mouse model

NeuroToxicology(2021)

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摘要
•Concentrated UFP exposure did not cause overt lung inflammation.•UFP exposure in 3xTgAD mice led to perturbations in microglia morphology.•3xTgAD mice exposed to UFP had elevated levels of phospho-tau immunoreactivity.•UFP-exposed 3xTgAD mice had decreased amyloid deposition.
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关键词
,GFAP,Iba1,HUCAPS,3xTgAD,NTg,UFP,PM,PM2.5,PM10,AD,pT205,HR,CI,ANOVA,BAL,SMPS,MPPD,CMD,GSD,PFA,LDH,TPER,AUC,LPS,IL1β,ELISA,SO2,pS199
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