Dosing Patterns In Treatment of Disabling Spasticity With Intrathecal Baclofen

Purpose The aim of this study was to describe and analyze dosing patterns for patients with ITB treatment over time and to identify possible subgroups demonstrating diversity in patterns. Design A retrospective design. Methods For 81 patients from six different hospitals, baclofen doses from the first 2 years of treatment were identified using medical records. Line graphs of each patient's doses were analyzed and grouped based on similarities in dosing pattern. Findings The analyses of the dosing patterns resulted in four different subgroups classified as stable, slow increase, rapid increase, and fluctuating. Conclusion The results highlight the clinical challenge of predicting dose development over time.