Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection

Fabiola Ciccosanti,Martina Di Rienzo,Alessandra Romagnoli,Francesca Colavita,Giulia Refolo,Concetta Castilletti,Chiara Agrati,Annalaura Brai,Fabrizio Manetti,Lorenzo Botta,Maria Rosaria Capobianchi,Giuseppe Ippolito,Mauro Piacentini,Gian Maria Fimia

Antiviral Research（2021）

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摘要

COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular proteins hijacked by viruses for their life cycle and develop host-oriented antiviral therapeutics.

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关键词

Antiviral drugs,COVID-19,Proteomics,Stress granules,DEAD RNA helicase,G3BP1

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