Sensitivity and specificity of CEST and NOE MRI in injured spinal cord in monkeys

Feng Wang,Zhongliang Zu,Tung-Lin Wu,Xinqiang Yan,Ming Lu,Pai-Feng Yang,Nellie E. Byun,Jamie L. Reed,John C. Gore,Li Min Chen

NeuroImage: Clinical（2021）

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摘要

•Compare sensitivity and specificity of CEST and NOE measures from 6-pool fitting.•Differentiate regional molecular signatures at and around spinal cord injury.•Provide parameters that improve the diagnostic accuracy of molecular alteration.•Down-sampled data acquisition can capture the characteristic molecular profile.•High translational potential for clinical assessment of spinal cord injury.

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关键词

MRI,Chemical exchange saturation transfer (CEST),Nuclear Overhauser enhancement (NOE),Spinal cord injury (SCI),Non-human primates (NHP)

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