Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation

Jonathan Paulo Agnes,Vitória Wibbelt Dos Santos,Raquel Nascimento das Neves,Rosângela Mayer Gonçalves,Marina Delgobo,Carolina Saibro Girardi,Débora Denardin Lückemeyer,Marcella de Amorim Ferreira, Sérgio José Macedo Júnior,Samantha Cristiane Lopes,Fernando Spiller,Daniel Pens Gelain,José Cláudio Fonseca Moreira,Rui Daniel Prediger,Juliano Ferreira,Alfeu Zanotto-Filho

The Journal of Pain（2021）

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摘要

•Antioxidants ameliorate OXA-induced peripheral neuropathy in tumor-bearing mice.•OXA promotes ROS production and inflammation in the spinal cord of mice.•Antioxidants abrogate ROS-induced spinal cord inflammation in OXA-treated mice.•Tlr4 knockout decreases spinal cord inflammation and mechanical allodynia.•Antioxidants do not impair the antitumor efficacy of OXA.

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Neuropathy,reactive oxygen species,cytokines,TLR4, chemotherapy,antioxidants

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