Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism

Teige R.S. Matthews-Palmer,Nayim Gonzalez-Rodriguez,Thomas Calcraft, Signe Lagercrantz,Tobias Zachs,Xiu-Jun Yu,Grzegorz J. Grabe,David W. Holden,Andrea Nans,Peter B. Rosenthal,Sarah L. Rouse,Morgan Beeby

Journal of Structural Biology（2021）

引用 11|浏览15

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摘要

•CryoEM of a full-length type III secretion system SctV resolves cytoplasmic but not transmembrane domains.•MD simulations show SctV protomers flexibly hinge.•Acidification expands the SctV ring by altering interprotomer interactions.

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关键词

SctV,Specificity switch,cryo-EM,Injectisome,Type III secretion system,Molecular dynamics

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