Four-repeat tauopathies

Thomas W. Rösler,Amir Tayaranian Marvian,Matthias Brendel,Niko-Petteri Nykänen,Matthias Höllerhage,Sigrid C. Schwarz,Franziska Hopfner,Thomas Koeglsperger,Gesine Respondek,Kerstin Schweyer,Johannes Levin,Victor L. Villemagne,Henryk Barthel,Osama Sabri,Ulrich Müller,Wassilios G. Meissner,Gabor G. Kovacs,Günter U. Höglinger

Progress in Neurobiology（2019）

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摘要

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative diseases defined by cytoplasmic inclusions predominantly composed of tau protein isoforms with four microtubule-binding domains. Progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease or glial globular tauopathy belong to the group of 4R-tauopathies.

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关键词

AD,AGD,AGE,ALS,ARTAG,bvFTD,CBD,CBS,CDK5,CMA,CSF,CTE,CxI,DLX1,EIF2AK3,eTau,FDG,FTD,FTLD,GGT,GSK-3,GWAS,HSPGs,iPSC,ISF,MAPT,MBD,MOBP,MSA,mTOR,NfL,NFT,O-GlcNAc,OGA,PD,PERK,PET,PHF,PiD,PSP,pTau,Rab,RS,SNPs,STX6,TDP-43,UPR,UPS

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