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Human MC4R Variants Affect Endocytosis, Trafficking and Dimerization Revealing Multiple Cellular Mechanisms Involved in Weight Regulation

Bas Brouwers,Edson Mendes de Oliveira,Maria Marti-Solano, Fabiola B. F. Monteiro,Suli-Anne Laurin,Julia M. Keogh,Elana Henning,Rebecca Bounds,Carole A. Daly,Shane Houston,Vikram Ayinampudi,Natalia Wasiluk,David Clarke,Bianca Plouffe,Michel Bouvier,M. Madan Babu,I. Sadaf Farooqi,Jacek Mokrosinski

Yearbook of pediatric endocrinology（2021）

Cited 36|Views40
Key words
obesity,MC4R,therapy,weight loss,GPCRs,β-arrestin,Gαs,melanocortin,MSH
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