Sulphur mustard induces progressive toxicity and demyelination in brain cell aggregate culture

Thomas W Sawyer,Yushan Wang,Yanfeng Song,Mercy Villanueva, Andres Jimenez

NeuroToxicology（2021）

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摘要

•Brain cell aggregates are comprised of all major brain cell types but vasculature.•Sulphur mustard (H) treatment induces progressive toxicity in brain cell aggregates.•H is a potent demyelinating agent in brain cell aggregates.•H significantly reduces VEGF levels in brain cell aggregates.

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关键词

Brain cell aggregate culture,Chemical warfare (CW),Demyelination,Neurotoxicity,Sulphur mustard (H: bis(2-chloroethyl) sulphide),Vascular endothelial growth factor (VEGF)

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