Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes

Taylor M Triolo,Laura Pyle,Sona Seligova,Liping Yu,Kimber Simmons,Peter Gottlieb,Carmella Evans-Molina,Andrea K Steck

Journal of Translational Autoimmunity（2021）

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摘要

•Higher PI:C ratios are associated with mIAA titers.•Trajectories of PI:C increase overtime in multiple antibody positive subjects.•PI:C could be a useful biomarker to trend in those at risk for type 1 diabetes.

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