Case Report: Placental Maternal Vascular Malperfusion Affecting Late Fetal Development And Multiorgan Infection Caused By Sars-Cov-2 In Patient With Pai-1 4g/5g Polymorphism

FRONTIERS IN MEDICINE(2021)

引用 4|浏览5
暂无评分
摘要
Background: Pregnant women are susceptible to the novel coronavirus (SARS-CoV-2), and the consequences for the fetus are still uncertain. Here, we present a case of a pregnant woman with subclinical hypothyroidism and a plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism who was infected with SARS-CoV-2 at the end of the third trimester of pregnancy, with unexpected evolution of death of the newborn 4 days postpartum.Methods: Nested PCR was performed to detect the virus, followed by ssDNA sequencing.Results: Transplacental transmission of SARS-CoV-2 can cause placental inflammation, ischemia, and neonatal viremia, with complications such as preterm labor and damage to the placental barrier in patients with PAI-1 4G/5G polymorphism.Conclusion: We showed a newborn with several damages potentially caused due to the PAI-1 polymorphisms carried by the mother infected with SARS-CoV-2 during pregnancy.
更多
查看译文
关键词
SARS-CoV-2, placenta infection, vascular malperfusion, multi-organ infection, vertical transmission
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要