Cytotoxicity Of Tin(Iv)-Based Compounds: A Review

The objective of this review is to summarise the achievements of tin-based compounds as potential anti-cancer agents in the last 10 years. Tin-based compounds attracted growing attention in many important scientific areas, especially in drug discovery. The motivation of tin-based as anticancer agents arises from the limitations of platinum-based drugs. The major challenge in drug discovery has become to find out the alternatives with enhanced selectivity and specificity towards target biomacromolecules. In this review, we have focussed our attention on tin-based compounds and cytotoxicity studies of tin-based compounds against cancer cells. This mini review also briefly discusses the possible mechanism of action of the tin-based compounds. (C) 2021 Elsevier Ltd. All rights reserved.