A Review on Statistical Methods Using Longitudinal Biomarkers for Disease EarlyDetection

Longitudinal biomarkers may be predictive for the early\r\ndetection of clinical outcomes. Tracking longitudinal\r\nbiomarkers as a way to identify early disease onset may\r\nhelp to reduce mortality from diseases that are more\r\ntreatable if detected early. This review provides a brief\r\nsummary of a recent publication on statistical approaches\r\nthat use longitudinal biomarkers for disease early detection.\r\nComparison of statistical methods and future research\r\ndirections in general disease early detection using\r\nlongitudinal biomarkers are presented.