Developmental Antecedents of Adult Macaque Neurogenesis: Early-Life Adversity, 5-HTTLPR Polymorphisms, and Adolescent Hippocampal Volume

Eric M Schoenfeld,Nishant K Gupta,Shariful A Syed,Anna V Rozenboym,Sasha L Fulton,Andrea P Jackowski,Tarique D Perera,Jeremy D Coplan

Journal of Affective Disorders（2021）

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摘要

•Early-life adversity and short 5-HTTLPR allele concertedly attenuate neurogenesis•Normalized adolescent hippocampal volume predicts ipsilateral adult neurogenesis•Developmental affective risk may be attributable to altered hippocampal plasticity

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关键词

Neurogenesis,Hippocampus,Early-Life Adversity,5-HTTLPR,Serotonin Transporter Gene,Nonhuman Primate

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