MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression

Xiaoyun Si,Qixian Chen, Jiechang Zhang,Wei Zhou,Lijun Chen,Jingjing Chen,Na Deng,Wei Li,Danan Liu,Long Wang, Linyan Shi, Weihong Sun,Haoyu Song,Lintao Zhong

Life Sciences（2022）

引用 9|浏览15

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摘要

•Little is known about the role of miR-23b in the formation of AAAs.•In vivo studies revealed that miR-23b overexpressing in angiotensin II-treated mice inhibited the formation of AAAs.•Therapeutic approaches designed to increase miR-23b expression will be beneficial for preventing AAAs formation.

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关键词

miR-23b,Abdominal aortic aneurysm,Angiotensin II,Vascular smooth muscle cells,Phenotypic switching

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