Genome Wide Association Study Of Acute Radiation Toxicity And Quality Of Life In Breast Cancer Patients - Results From The Requite Cohort Study

Background: Around a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity, which may adversely affect breast cosmesis and quality of life (QoL). If patients at high risk of toxicity could be identified at diagnosis, this could be taken into account when discussing treatment options. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with acute radiation toxicity and change in QoL on completion of radiotherapy.