Arundic acid (ONO-2526) inhibits stimulated-S100B secretion in inflammatory conditions

Adriana Fernanda K. Vizuete, Juliana de Lima Cordeiro,Juliana Dalibor Neves,Marina Seady,Lucas Kich Grun,Florencia María Barbé-Tuana,Marina Concli Leite,Carlos Alexandre Netto,Carlos-Alberto Gonçalves

Neuroscience Letters（2021）

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摘要

•Neuroprotective activity of AA is based on changes in S100B synthesis.•We studied the effect of AA on S100B secretion in astrocytes and hippocampal slices.•AA inhibited LPS-stimulated S100B secretion in astrocyte cultures.•AA also inhibited TNF-α-stimulated S100B secretion by hippocampal slices.•Protection by AA under neuroinflammatory conditions may be mediated by decreased S100B secretion.

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关键词

AA,GFAP,ICV,LPS,S100B,TNF-α

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